Neonatal infectious hemophagocytic lymphohistiocytosis

Nada Boutid, Hakim Rahmoune, Mounira Amrane, Noureddine Boutaghane, Ahmed Aziz Bousfiha, Belkacem Bioud

Abstract


Hemophagocytic lymphohistiocytosis (HLH) is a disorder of the mononuclear phagocytic system and a severe, life-threatening syndrome due to an excessive immune activation. This hyperinflammatory condition is often triggered by a variety of agents or events, mostly genetic or infectious; and its scarcity in the neonatal period often delay diagnosis and adequate management. We report a peculiar neonatal case with multivisceral involvement, managed promptly and aggressively. Discussing the most important relevant points in both diagnosis and therapy of this peculiar disorder is highlighted in purpose of increasing awareness and enhancing early determinant recognition.


Keywords


Hemophagocytic lymphohistiocytosis, neonatal period, life-threatening, diagnosis, therapy

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References


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