Effect of cerebrolysin in patients with ischemic stroke: A double-blind randomized control study

Seyed Ali Mousavi, Azam Moradi, Omid Mirmosayyeb, Mansour Salehi, Fariborz Khorvash

Abstract


We investigated the effect of cerebrolysin compared with placebo efficacy in patients with ischemic stroke. A total of 50 patients with ischemic stroke participate in this randomized double-blind placebo-controlled study. Patients were randomly divided into two groups; main group (n=25) was treated by 30cc IV cerebrolysin daily for 5 days. Control group (n=25) administrated 30 cc IV normal saline as a placebo daily during first five days of stroke attack. Three scoring system was used in the present study: National Institutes of Health Stroke Scale (NIHSS) on admission and after five days, and Barthel and Rankin’s scale after the 90 days. Data were analyzed by SPSS 16 using t-test. P-value less than 0.05 considered as significant level. The NIHSS score showed no significantly difference after 5 days (independent t-test, P = 0.195). There was a significant difference between Barthel and Rankin’s scale after 90 days (P = 0.039 and P = 0.008 respectively). In conclusion, cerebrolysin prevented the development of ischemic stroke’s sign and symptoms through 90 days.


Keywords


Cerebrolysin, ischemic stroke, neuroprotection

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References


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