Effect of post operation antibiotic on infectious complication of suppurative appendicitis

Abdoulhossein Davoodabadi, Esmail Kashi, Hamid Pourvali, Hossein Akbari


The most common complication of suppurative appendicitis is surgical wound infection and prophylactic antibiotics being used to prevent it. This study evaluates the relationship between postoperative antibiotics and wound infection rate and intra-abdominal infectious complications after suppurative stage appendectomy. This study was a single-blind randomized clinical trial. The population consisted of patients ageing 18-50 years old, admitted to Kashan Shahid Beheshti General Hospital from November 2013, to May, 2016 with the diagnosis of acute suppurative appendicitis. To achieve uniformity in operative procedure, a standard operative protocol was applied. After the operation, patients in group A received 1 gram ceftriaxone every 12 hours plus 500 mg metranidazol intravenously during hospitalization and 3 days after discharge, orally and patients in group B received no antibiotics after operation.Using the SPSS-18 statistical software, the collected data were analyzed. In all statistical tests a p < 0.05 was considered statistically significant. Of 140 patients, 90 (64%) were men and 50 (36%) were female and the mean age was the 29.03 ± 10.21 years. The mean operative times was 60 ± 10 min and the mean hospital stay were 48 ± 4 and 48 ± 6 hour in A and B groups respectively. This study showed that the incidence of surgical site infection and intra-abdominal abscess in both group was similar and also the temperature, white blood cell count and polymorphonuclear cells in the two groups were similar. The incidence of infectious complication in patients who had not received postoperative antibiotics was similar to the group that received antibiotics thus indicating no need for any additive postoperative antibiotics.


Appendicitis, postoperative antibiotics, suppurative appendicitis

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