Migraine headaches as a preliminary symptom for cognitive decline

Ahad Hasan Syed Hasani, Melika Faani

Abstract


Migraine headaches are amongst the most prevalent neurological disorders. Dementia on the other hand, is classified as a neurodegenerative disease with symptoms of slow progressive memory loss and cognitive decline. Identifying the preliminary signs and symptoms of such neurological diseases are crucial in preventing the onset of such disease. In this review article, we analyzed several studies signifying and or contradicting the claim of migraine headaches as a preliminary symptom of dementia. This can ultimately aid in focusing specific treatments to reduce the risk of patients developing dementia. Databases including Google Scholar, PubMed, and NCBI were searched by using keywords including migraine, dementia, association, symptom, etc. This study analyzed articles that were sought through various databases. Several studies signified a positive correlation between the two diseases. Studies that contradicted this claim, were vastly outnumbered by studies that depicted the claim to be true. It was eminent that preventing and treating migraine headaches in patients with a high-risk profile of dementia should be considered and studied more extensively.


Keywords


Migraine, Dementia, Cognitive Decline, Neurodegenerative Disease, Headache

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References


Stovner, L., et al., The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia, 2007. 27(3): p. 193-210.

Olla, D., et al., Migraine Treatment. Clinics in Plastic Surgery, 2020. 47(2): p. 295-303.

Ha, H. and A. Gonzalez, Migraine Headache Prophylaxis. Am Fam Physician, 2019. 99(1): p. 17-24.

Burch, R.C., D.C. Buse, and R.B. Lipton, Migraine: Epidemiology, Burden, and Comorbidity. Neurol Clin, 2019. 37(4): p. 631-649.

Goadsby, P.J., Pathophysiology of migraine. Annals of Indian Academy of Neurology, 2012. 15(Suppl 1): p. S15-S22.

Rone-Adams, S., et al., Understanding Dementia: Etiology, Communication, and Exercise Intervention. 2013. 35(4): p. 88-98.

Anstey, K.J., et al., Estimates of probable dementia prevalence from population-based surveys compared with dementia prevalence estimates based on meta-analyses. BMC Neurol, 2010. 10: p. 62.

Barry, P.P. and M.A. Moskowitz, The diagnosis of reversible dementia in the elderly. A critical review. Arch Intern Med, 1988. 148(9): p. 1914-8.

Joling, K.J., et al., Time from diagnosis to institutionalization and death in people with dementia. Alzheimers Dement, 2020. 16(4): p. 662-671.

Ikeda, Y., et al., Association between Daily Activities and Behavioral and Psychological Symptoms of Dementia in Community-Dwelling Older Adults with Memory Complaints by Their Families. Int J Environ Res Public Health, 2020. 17(18).

Cipriani, G., et al., Personality and dementia. J Nerv Ment Dis, 2015. 203(3): p. 210-4.

Kostev, K., J. Bohlken, and L. Jacob, Association Between Migraine Headaches and Dementia in More than 7,400 Patients Followed in General Practices in the United Kingdom. J Alzheimers Dis, 2019. 71(1): p. 353-360.

Jensen R. Diagnosis, epidemiology, and impact of tension-type headache. Curr Pain Headache Rep. 2003; 7:455–459. PMID: 1460450414.Crystal SC, Robbins MS. Epidemiology of tension-type headache. Curr Pain Headache Rep. 2010;14:449–454. doi: 10.1007/s11916-010-0146-2 PMID: 20865353

Stræte Røttereng AK, Bosnes O, Stordal E, Zwart JA, Linde M, Stovner LJ, et al. Headache as a predictor for dementia: The HUNT Study. J Headache Pain. 2015; 16:89. doi:10.1186/s10194-015-0573-xPMID: 26471177

Baars MA, van Boxtel MP, Jolles J. Migraine does not affect cognitive decline: results from the Maastricht aging study. Headache. 2010; 50:176–184. doi: 10.1111/j.1526-4610.2009.01572.x PMID:19925622

Fereshtehnejad SM, Damangir S, Cermakova P, Aarsland D, Eriksdotter M, Religa D. Comorbidity profilein dementia with Lewy bodies versus Alzheimer’s disease: a linkage study between the SwedishDementia Registry and the Swedish National Patient Registry. Alzheimers Res Ther. 2014; 6:65. doi: 10.1186/s13195-014-0065-2 PMID: 25478027

Gaist D, Pedersen L, Madsen C, Tsiropoulos I, Bak S, Sindrup S, et al. Long-term effects of migraine on cognitive function: a population-based study of Danish twins. Neurology. 2005; 64:600–607. PMID:15728279

Kalaydjian A, Zandi PP, Swartz KL, Eaton WW, Lyketsos C. How migraines impact cognitive function: findings from the Baltimore ECA. Neurology. 2007; 68:1417–1424. PMID: 17452587

Rist PM, Dufouil C, Glymour MM, Tzourio C, Kurth T. Migraine and cognitive decline in the populationbased EVA study. Cephalalgia. 2011; 31:1291–1300. doi: 10.1177/0333102411417466 PMID:21816772

Rist PM, Kang JH, Buring JE, Glymour MM, Grodstein F, Kurth T. Migraine and cognitive decline among women: prospective cohort study. BMJ. 2012; 345:e5027–e5027. doi: 10.1136/bmj.e5027 PMID: 22875950

Rist PM, Kurth T. Migraine and cognitive decline: A topical review. Headache. 2013; 53:589–598. doi:10.1111/head.12046 PMID: 23405909

Caselli RJ. Current issues in the diagnosis and management of dementia. Semin Neurol. 2003;23:231–240. PMID: 14722819

Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, et al. Global prevalence of dementia:a Delphi consensus study. Lancet. 2005; 366:2112–2117. PMID: 1636078

Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, et al. Global prevalence of dementia:

Morris JC. Dementia update 2003. Alzheimer Dis Assoc Disord. 2003; 17:245–258. PMID: 14657790

Alzheimer’s Association. Alzheimer’s disease facts and figures. Alzheimer’s Dement. 2013; 9:110–133.

Qiu C, Xu W, Fratiglioni L. Vascular and psychosocial factors in Alzheimer’s disease: Epidemiological evidence toward intervention. J Alzheimer’s Dis. 2010; 20:689–697

Sahathevan R, Brodtmann A, Donnan GA. Dementia, stroke, and vascular risk factors; a review. Int JStroke. 2012; 7:61–73. doi: 10.1111/j.1747-4949.2011.00731.x PMID: 22188853

Schram MT, Euser SM, de Craen AJ, Witteman JC, Frölich M, Hofman A, et al. Systemic markers ofinflammation and cognitive decline in old age. J Am Geriatr Soc. 2007; 55:708–716. PMID: 17493190

Poblador-Plou B, Calderón-Larrañaga A, Marta-Moreno J, Hancco-Saavedra J, Sicras-Mainar A, Soljak M, et al. Comorbidity of dementia: a cross-sectional study of primary care older patients. BMC Psychiatry.2014; 14:84. doi: 10.1186/1471-244X-14-84 PMID: 24645776

Köhler S, Buntinx F, Palmer K, van den Akker M. Depression, vascular factors, and risk of dementia in primary care: a retrospective cohort study. J Am Geriatr Soc. 2015; 63:692–698. doi: 10.1111/jgs.13357 PMID: 25900484

Ringman JM, Romano JD, Medina LD, Rodriguez-Agudelo Y, Schaffer B, Varpetian A, et al. Increased prevalence of significant recurrent headache in preclinical familial Alzheimer’s disease mutation carriers. Dement Geriatr Cogn Disord. 2008; 25:380–384. doi: 10.1159/000121986 PMID: 18376127

Chuang CS, Lin CL, Lin MC, Sung FC, Kao CH. Migraine and risk of dementia: A nationwide retrospective cohort study. Neuroepidemiology. 2013; 41:139–145. doi: 10.1159/000353559 PMID: 23921376

Hagen K, Stordal E, Linde M, Steiner TJ, Zwart JA, Stovner LJ. Headache as a risk factor for dementia: A prospective population-based study. Cephalalgia. 2013; 34:327–335. doi: 10.1177/0333102413513181 PMID: 24265286

Launer LJ, Andersen K, Dewey ME, et al. Rates and risk factors for dementia and Alzheimer’s disease: results from EURODEM pooled analyses. Neurology 1999;52:7884

Barford, A., Dorling, D., Smith, G. D., & Shaw, M. (2006). Life expectancy: women now on top everywhere.

Mulnard RA, Cotman CW, Kawas C, et al. Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. JAMA 2000;283:1007–15

Rigaud AS, Andre G, Vellas B, Touchon J,Pere JJ, Loria-Kanza Y. Traitement estroprogestatifen association a` la rivastigmine chez des femmes me´nopause´es atteintes de la maladie d’Alzheimer. Presse Med 2003;32:1649–54

Shumaker SA, Legault C, Kuller L, et al. Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women’s Health Initiative Memory Study. JAMA 2004;291:2947–58

Lipton RB, Stewart WF, Diamond S, DiamondML, Reed M: Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache 2001;41: 646–657.

Kruit MC, van Buchem MA, Hofman PA,Bakkers JT, Terwindt GM, Ferrari MD, Launer LJ: Migraine as a risk factor for subclinical brain lesions. JAMA 2004; 291: 427–434.

Vermeer SE, Prins ND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MM: Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med 2003; 348:1215–1222.

Pearson AJ, Chronicle EP, Maylor EA, Bruce LA: Cognitive function is not impaired in people with a long history of migraine: a blinded study. Cephalalgia 2006; 26: 74–80.

Gaist D, Pedersen L, Madsen C, Tsiropoulos I, Bak S, Sindrup S, McGue M, Rasmussen BK, Christensen K: Long-term effects of migraine on cognitive function: a population-based study of Danish twins. Neurology 2005; 64: 600–607.

Jelicic M, van Boxtel MP, Houx PJ, Jolles J: Does migraine headache affect cognitive function in the elderly? Report from the Maastricht Aging Study (MAAS). Headache 2000; 40: 715–719

Calandre EP, Bembibre J, Arnedo ML, Becerra D: Cognitive disturbances and regional cerebral blood flow abnormalities in migraine patients: their relationship with the clinical manifestations of the illness. Cephalalgia 2002; 22: 291–302.

Mulder EJ, Linssen WH, Passchier J, Orlebeke JF, de Geus EJ: Interictal and postictal cognitive changes in migraine. Cephalalgia 1999; 19: 557–565;disc 541.

Le Pira F, Zappalà G, Giuffrida S, Lo Bartolo ML, Reggio E, Morana R, Lanaia F: Memory disturbances in migraine with and without aura: a strategy problem? Cephalalgia 2000; 20: 475–478

Neuroepidemiology 2013; 41:139–145

Wang SJ, Chung CS, Chankrachang S, Ravishankar K, Merican JS, Salazar G, et al. Migraine disability awareness campaign in Asia: migraine assessment for prophylaxis. Headache 2008; 48:1356–65.

Lipton RB, Stewart WF, Diamond S, Diamond ML, Reed M. Prevalence and burden of migraine in the United States: data from the American migraine study II. Headache 2001; 41:646–57

Stovner LJ, Zwart JA, Hagen K, Terwindt GM, Pascual J. Epidemiology of headache in Europe. Eur J Neurol 2006; 13:333–45

Scher AI, Terwindt GM, Picavet HSJ, Verschuren WMM, Ferrari MD, Launer LJ. Cardiovascular risk factors and mi- graine. The GEM population-based study. Neurology 2005; 64:614–20.

Rodriguez-Sainz A, Pinedo-Brochado A, Sa ́ nchez- Menoyo JL, Ruiz-Ojeda J, Escalza Cortina I, Garcia- Monco JC. Migraine, stroke and epilepsy: underlying and interrelated causes, diagnosis and treatment. Curr Treat Options Cardiovasc Med 2013; 15:322–34

Leniger T, Diener HC, Hufnagel A. Altered cerebral excitabil- ity and spreading depression. Causes for the comorbidity of epilepsy and migraine? Der Nervenarzt 2003; 74:869–74.

Rogawski MA. Common pathophysiologic mechanisms in migraine and epilepsy. Arch Neurol 2008; 65:709–14.

Hauser WA, Annegers JF, Kurland LT. Prevalence of epilepsy in Rochester, Minnesota: 1940–1980. Epilepsia 1991; 32:429–45

Benbadis SR, Allen Hauser W. An estimate of the prevalence of psychogenic non-epileptic seizures. Seizure 2000; 9:280–1.

Ottman R, Lipton RB. Comorbidity of migraine and epilepsy. Neurology 1994; 44:2105 10

Bigal ME, Lipton RB, Cohen J, Silberstein SD. Epilepsy and migraine. Epilepsy Behav 2003; 4:S13–24.

Elahi FM, Miller BL. A clinicopathological approach to the diagnosis of dementia. Nat Rev Neurol. 2017;13(8):457-476.

Prince M, Ali GC, Guerchet M, Prina AM, Albanese E, Wu YT. Recent global trends in the prevalence and incidence of dementia,and survival with dementia. Alzheimer's Res Therapy. 2016;8(1):23.

Collaborators GBDH. Global, regional, and national burden of migraine and tension-type headache, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2018;17(11):954-976.

Kruit MC, van Buchem MA, Launer LJ, Terwindt GM, Ferrari MD. Migraine is associated with an increased risk of deep white matter lesions, subclinical posterior circulation infarcts and brain iron accumulation: The population-based MRI CAMERA study. Cephalalgia. 2010;30(2):129-136.

Kurth T, Mohamed S, Maillard P, et al. Headache, migraine, and structural brain lesions and function: population based Epidemiology of Vascular Ageing-MRI study. BMJ. 2011;342: c7357.

Waller R, Narramore R, Simpson JE, et al. Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer's and small vessel disease pathologies. Brain Pathol. 2021;31(3):e12928. https://doi.org/10.1111/bpa.12928

Edvinsson L, Haanes KA, Warfvinge K. Does inflammation have a role in migraine? Nat Rev Neurol. 2019;15(8):483-490.

Lee SY, Lim JS, Oh DJ, Kong IG, Choi HG. Increased risk of neurodegenerative dementia in women with migraines: a nested case-control study using a national sample cohort. Medicine. 2019;98(7):e14467

Martins IP, Maruta C, Alves PN, et al. Cognitive aging in migraine sufferers is associated with more subjective complaints but similar age-related decline: a 5-year longitudinal study. J Headache Pain. 2020;21(1):31.

Ackley, S. F., Rist, P. M., Brenowitz, W. D., Graff, R. E., & Glymour, M. M. (2020). The association between migraine genetic risk and dementia: A Mendelian randomization study. In Alzheimer’s & Dementia (Vol. 16, Issue S3). Wiley. https://doi.org/10.1002/alz.045405

Chabriat, H., et al., Autosomal dominant migraine with MRI white‐matter abnormalities mapping to the CADASIL locus. 1995. 45(6): p. 1086-1091.

Finsterer, J., Cognitive decline as a manifestation of mitochondrial disorders (mitochondrial dementia). J Neurol Sci, 2008. 272(1-2): p. 20-33.

https://www.mayoclinic.org/diseasesconditions/dementia/symptomscauses/syc20352013 :~:text=Alzheimer's%0disease%20is%20the%20most,dementia%20symptoms%20might%20be%20reversible.

Fereshtehnejad, S.-M., et al., Comorbidity profile in dementia with Lewy bodies versus Alzheimer’s disease: a linkage study between the Swedish Dementia Registry and the Swedish National Patient Registry. Alzheimer's Research & Therapy, 2014. 6(5): p. 65.

Lee, S.-Y. et al, increased risk of neurodegenerative dementia in women with migraines: A nested case-control study using a national sample cohort. Medicine, 2019. 98(7): p. e14467

Etminan, M., et al., Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies. 2005. 330(7482): p. 63.

De Benedittis, G., et al., Magnetic resonance imaging in migraine and tension‐type headache. 1995. 35(5): p. 264-268.

Rocca, M., et al., A magnetization transfer imaging study of the brain in patients with migraine. 2000. 54(2): p. 507-507.

Fazekas, F., et al., The prevalence of cerebral damage varies with migraine type: a MRI study. 1992. 32(6): p. 287-291.

Paemeleire, K., Brain lesions and cerebral functional impairment in migraine patients. Journal of the Neurological Sciences, 2009. 283(1): p. 134-136.

Le Pira, F., et al., Memory disturbances in migraine with and without aura: a strategy problem? 2000. 20(5): p. 475-478.

Riva, D., et al., Cognitive and behavioural effects of migraine in childhood and adolescence. 2006. 26(5): p. 596-603.

Calandre, E., et al., Cognitive disturbances and regional cerebral blood flow abnormalities in migraine patients: their relationship with the clinical manifestations of the illness. 2002. 22(4): p. 291-302.

Mulder, E., et al., Interictal and postictal cognitive changes in migraine. 1999. 19(6): p. 557-565.

Hooker, W.D. and N.H.J.A.o.N. Raskin, Neuropsychologic alterations in classic and common migraine. 1986. 43(7): p. 709-712.

Le Pira, F., et al., Relationship between clinical variables and cognitive performances in migraineurs with and without aura. 2004. 19: p. 101-106.

Palmer, J. and E.P.J.C. Chronicle, Cognitive processing in migraine: a failure to find facilitation in patients with aura. 1998. 18(3): p. 125-132.

Bell, B.D., et al., Neuropsychological functioning in migraine headache, nonheadache chronic pain, and mild traumatic brain injury patients. 1999. 14(4): p. 389-399.

Jelicic, M., et al., Does migraine headache affect cognitive function in the elderly? Report from the Maastricht Aging Study (MAAS). 2000. 40(9): p. 715-719.

Leijdekkers, M.L., et al., Migraine patients cognitively impaired? 1990. 30(6): p. 352-358.

Pearson, A., et al., Cognitive function is not impaired in people with a long history of migraine: a blinded study. 2006. 26(1): p. 74-80.

https://www.who.int/mediacentre/factsheets/fs277/en/

https://www.who.int/mediacentre/factsheets/fs277/en/

Simon RP, Aminoff MJ, Greenberg DA (2009). Clinical neurology (7 ed.). New York, N.Y: Lange Medical Books/McGraw-Hill. pp. 85–88. ISBN 9780071664332.

Headache Classification Subcommittee of the International Headache Society (2004). "The International Classification of Headache Disorders: 2nd edition". Cephalalgia. 24 Suppl 1 (Suppl 1): 9–160. doi:10.1111/j.1468-2982.2004.00653.x. PMID 14979299. as PDF Archived 31 March 2010 at the Wayback Machine

Headache Classification Subcommittee of the International Headache Society (2004). "The International Classification of Headache Disorders: 2nd edition". Cephalalgia. 24 Suppl 1 (Suppl 1): 9–160. doi:10.1111/j.1468-2982.2004.00653.x. PMID 14979299. as PDF Archived 31 March 2010 at the Wayback Machine

Lipton RB, Bigal ME, Diamond M, et al. Migraine prevalence, disease burden, and the need for preventive therapy. Neurology 2007;68(5):343–9.

Piane M, Lulli P, Farinelli I, Simeoni S, De Filippis S, Patacchioli FR, Martelletti P (December 2007). "Genetics of migraine and pharmacogenomics: some considerations". The Journal of Headache and Pain. 8(6): 334–9. doi:10.1007/s10194-007-0427-2. PMC 2779399. PMID 18058067

Lay CL, Broner SW (May 2009). "Migraine in women". Neurologic Clinics. 27 (2): 503 11. doi:10.1016/j.ncl.2009.01.002. PMID 19289228.

Stovner LJ, Zwart JA, Hagen K, Terwindt GM, Pascual J (April 2006). "Epidemiology of headache in Europe". European Journal of Neurology. 13 (4): 333–45. doi:10.1111/j.1468-1331.2006.01184.x. PMID 16643310. S2CID 7490176

Ashina M (November 2020). "Migraine". The New England Journal of Medicine. 383 (19): 1866–1876. doi:10.1056/NEJMra1915327. PMID 33211930. S2CID 227078662.

Sinforiani, E., et al., Analysis of higher nervous functions in migraine and cluster headache. 1987. 2(1): p. 69-77.

Gaist, D., et al., Long-term effects of migraine on cognitive function: a population-based study of Danish twins. 2005. 64(4): p. 600-607.

Joutel, A., et al., Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. 1996. 383(6602): p. 707-710.

Sas, K., et al., Dementia, stroke and migraine — Some common pathological mechanisms. Journal of the Neurological Sciences, 2010. 299(1): p. 55-65.

Haan, J., G.M. Terwindt, and M.D.J.N.c. Ferrari, Genetics of migraine. 1997. 15(1): p. 43-60

Lay CL, Broner SW (May 2009). "Migraine in women". Neurologic Clinics. 27 (2): 503–11. doi:10.1016/j.ncl.2009.01.002. PMID 19289228.

Gobel H. "1. Migraine". ICHD-3 The International Classification of Headache Disorders 3rd edition. Retrieved 22 October 2020


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