Neonatal infectious hemophagocytic lymphohistiocytosis

Authors

  • Nada Boutid Pediatrics department, University Hospital of Setif, Setif University, Algeria
  • Hakim Rahmoune Pediatrics department, University Hospital of Setif, Setif University, Algeria
  • Mounira Amrane Biochemistry department University Hospital of Setif, Setif University, Algeria
  • Noureddine Boutaghane Neonatology Unit, N.Hammoud University Hospital; Algiers-1 University, Algeria
  • Ahmed Aziz Bousfiha Pediatric Clinical Immunology Unit, Casablanca Children Hospital; Hassan II University, Morocco
  • Belkacem Bioud Pediatrics department, University Hospital of Setif, Setif University, Algeria

Keywords:

Hemophagocytic lymphohistiocytosis, neonatal period, life-threatening, diagnosis, therapy

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a disorder of the mononuclear phagocytic system and a severe, life-threatening syndrome due to an excessive immune activation. This hyperinflammatory condition is often triggered by a variety of agents or events, mostly genetic or infectious; and its scarcity in the neonatal period often delay diagnosis and adequate management. We report a peculiar neonatal case with multivisceral involvement, managed promptly and aggressively. Discussing the most important relevant points in both diagnosis and therapy of this peculiar disorder is highlighted in purpose of increasing awareness and enhancing early determinant recognition.

Author Biographies

Nada Boutid, Pediatrics department, University Hospital of Setif, Setif University, Algeria

Pediatrics department

Assistant Professor

Hakim Rahmoune, Pediatrics department, University Hospital of Setif, Setif University, Algeria

Department of pediatrics

Assistant professor 

 

Mounira Amrane, Biochemistry department University Hospital of Setif, Setif University, Algeria

Biochemistry department

Associate Professor

Noureddine Boutaghane, Neonatology Unit, N.Hammoud University Hospital; Algiers-1 University, Algeria

Neonatology Unit,N.Hammoud University Hospital; Algiers, Algeria

Assistant Professor of Pediatrics

Ahmed Aziz Bousfiha, Pediatric Clinical Immunology Unit, Casablanca Children Hospital; Hassan II University, Morocco

Pediatric Clinical Immunology Unit, Casablanca Children Hospital; Hassan II University, Morocco

Professor of pediatrics

Belkacem Bioud, Pediatrics department, University Hospital of Setif, Setif University, Algeria

Pediatrics department, University Hospital of Setif, Setif University, Algeria

Professor of Pediatrics

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Published

2017-01-11

Issue

Vol. 4 No. 1 (2017)

Section

Articles

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