American Journal of Experimental and Clinical Research
https://ajecr.org/index.php/ajecr
<p style="margin: 0mm 0mm 0pt;"> </p><p style="margin: 0mm 0mm 0pt;"><span style="color: black; font-family: 'Verdana',sans-serif; font-size: 9pt;" lang="EN-US"><span style="color: #2e75b6; font-family: 'Verdana',sans-serif; font-size: 9pt; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 'MS 明朝'; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US; mso-fareast-language: JA; mso-bidi-language: AR-SA; mso-themecolor: accent1; mso-style-textfill-fill-color: #2E75B6; mso-style-textfill-fill-themecolor: accent1; mso-style-textfill-fill-alpha: 100.0%; mso-themeshade: 191;" lang="EN-US"><a title="NLM" href="https://www.ncbi.nlm.nih.gov/nlmcatalog/?term=Am+J+Exp+Clin+Res" target="_blank"><strong><span style="color: #2e75b6; font-family: 'Verdana',sans-serif; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: minor-bidi; mso-themecolor: accent1; mso-style-textfill-fill-color: #2E75B6; mso-style-textfill-fill-themecolor: accent1; mso-style-textfill-fill-alpha: 100.0%; mso-themeshade: 191;">NLM ID: 101716971 [Serial]</span></strong></a></span></span></p><p style="margin: 0mm 0mm 0pt;"> </p><p style="vertical-align: top;"><span style="color: black; font-family: 'Verdana',sans-serif; font-size: 9pt;" lang="EN-US"><span style="line-height: 107%; font-family: 'Calibri',sans-serif; font-size: 11pt; mso-bidi-font-family: 'Cordia New'; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: PMingLiU; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US; mso-fareast-language: ZH-TW; mso-bidi-language: AR-SA;"><span style="line-height: 107%; font-family: 'Calibri',sans-serif; font-size: 11pt; mso-bidi-font-family: 'Cordia New'; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: PMingLiU; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US; mso-fareast-language: ZH-TW; mso-bidi-language: AR-SA;"><span style="color: black; font-family: 'Verdana',sans-serif; font-size: 9pt;" lang="EN-US"><a title="AJECR" href="/index.php/ajecr" target="_blank"><img src="data:image/png;base64,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" alt="" /></a> The<strong><span style="font-family: 'Verdana',sans-serif; mso-bidi-font-family: 'MS Pゴシック';"> American Journal of Experimental and Clinical Research (AJECR)</span></strong> [ISSN 2330-9245 (Online)] is the official journal of the <a title="HOT" href="http://waarm.or.jp/" target="_blank"><span style="color: #006699;">World Academy of Anti-aging and Regenerative Medicine (WAARM)</span></a> . It is a scholarly multidisciplinary peer reviewed open access journal which provides a forum for scientific information exchange in the fields of Medical, Dental, Pharmaceutical, Nursing, Veterinary and Biological Science researches. The AJECR considers the policies of <a title="COPE" href="https://publicationethics.org/resources/code-conduct" target="_blank"><span style="color: #006699; font-family: 'Verdana',sans-serif; mso-bidi-font-family: 'MS Pゴシック';">COPE (Committee of Publication Ethics)</span></a> and <a title="ICMJE" href="http://www.icmje.org/recommendations/" target="_blank"><span style="color: #006699; font-family: 'Verdana',sans-serif; mso-bidi-font-family: 'MS Pゴシック';">International Committee of Medical Journal Editors (ICMJE)</span></a> in conducting, reporting, editing and publication of scholarly research works in medical journals. </span><span style="color: black; font-family: 'Verdana',sans-serif; font-size: 9pt;" lang="EN-US">The journal publishes Editorials, Original articles, Review articles, Short communications, Case reports, Methods/techniques and Letters to the editor/correspondences.</span></span></span></span></p>American Journal of Experimental & Clinical Researchen-USAmerican Journal of Experimental and Clinical Research2330-9237<p>Authors who publish with the American Journal of Experimental and Clinical Resaerch (AJECR) agree to the following terms:</p><ol type="a"><li>Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a <a title="CC BY-NC-ND" href="http://creativecommons.org/licenses/by-nc-nd/3.0/" target="_blank">Creative Commons Attribution License (CC BY-NC-ND)</a> that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.</li><li>Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.</li><li>Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See <a title="The Edffect of Oppen Access" href="http://opcit.eprints.org/oacitation-biblio.html" target="_self">The Effect of Open Access</a>).</li></ol>Assessing parenting capacity to identify RSV symptoms and the impact on their children’s health: A brief report
https://ajecr.org/index.php/ajecr/article/view/176
<p>Respiratory syncytial virus (RSV) is a viral infectious disease that has detrimentally affected the quality of life in children younger than 2 years of age since it was discovered in 1956. It is the major cause of lower respiratory tract illness in young children. So effectively does RSV spread that essentially all persons have experienced RSV infection within the first few years of life. RSV is estimated to cause up to 75% of all infant bronchiolitis and 40% of all pediatric pneumonia. RSV can manifest in different ways, causing a myriad of symptoms which are as follows: (1) cough; (2) shortness of breath; (3) fever; (4) wheezing; (5) decrease in appetite; and (6) runny nose. Data collection methods for this study consisted of the utilization of primary methods such as interviewing. Interviews conducted in either Spanish or English were utilized for data collection, accommodating the local Hispanic population. Seemingly, a weak negative correlation exists between early identification of RSV and oxygen requirements upon inpatient admittance and a weak positive correlation exists between early identification of RSV and length of hospital stay. This study concludes the need for additional research among the Hispanic population due to lack of information in parenting capacity to identify RSV symptoms.</p>José Andres Isla GomezNicholas Pereira
Copyright (c) 2023 American Journal of Experimental and Clinical Research
2023-12-212023-12-21101465468Clinicopathologic and survival study of patients with Ewing family of tumors: A retrospective-analytical study
https://ajecr.org/index.php/ajecr/article/view/179
<p class="Abstract">With significant mortality among malignancies, Ewing's family of tumors stands out as one of the most malignant cancers in young patients. This study aims to investigate clinicopathological characteristics and the impact of demographic and treatment types on survival. This retrospective-analytical study was conducted using the census method at Shahid Sadoughi Hospital in Yazd. The study included all patients with Ewing's family of tumors referred to these hospitals from 2011 to 2018. Demographic and disease characteristics were collected from the registry and analyzed using SPSS v.17. Fifty patients were enrolled in the study, with a mean age of 19.14±15.92 years. The lower extremity (30%) and abdominopelvic (24%) were the most common sites of the primary tumor, respectively. The mean tumor size was 5.76 ± 3.92 cm, and metastasis occurred in 16% of patients. Among them, 42% underwent combination therapy (chemotherapy/radiotherapy/ surgery), and 40% underwent chemotherapy + surgery. The disease relapsed in 62% of patients, and the most common site of recurrence was the chest wall (38%). The mean overall survival was 87.82 ± 11.54 months. Tumor location was associated with overall survival. Gender, age group, tumor size, and treatment type did not affect overall survival (P> 0.05). The mean survival until disease recurrence was 57.74 ± 7.74 months. It was concluded that recurrence is common in Ewing sarcomas, with the chest wall being the most common site of recurrence. Overall survival is linked to tumor location.</p>Shokouh Taghipour ZahirMaryam MirzaeiSeyed Mohammadreza MortazavizadehFarzan SafiDahajKoorosh RahmaniHamidreza MohammadiSajad Sadeghinejad-Alamabadi
Copyright (c) 2023 American Journal of Experimental and Clinical Research
2023-12-212023-12-21101469473Review of antibiotics therapy in ventilator associated pneumonia
https://ajecr.org/index.php/ajecr/article/view/6518
<p><strong>Abstract. </strong>A significant cause of morbidity and mortality was ranked as ventilator associated pneumonia (VAP). Therefore studies based on evidence-based pharmacotherapy could help in preventing multiple drug resistance and microorganism colonization. Experts suggested an 8 or 14-21 days course of vigilant antibiotics. Therefore, to reduce toxicity and cost, this systematic review aims to investigate updated antibiotic regimens for VAP. Web of Science, PubMed and Google Scholar were searched. New-onset pneumonia that developing more than 48 hours after endotracheal intubation was defined as VAP. Regarding pulmonary recurrent or excess mortality an 8 days course antibiotic therapy showed appropriate. For treatment of resistant pathogens with high minimum inhibitory concentrations, aerosolized antimicrobilas suggested more effective. Monitoring fever, prolcalcitonin values, C-reactive protein and PaO2/FiO(2) should also be considered. In addition report indicated that serum prolcalcitonin reduces the exposure of antibiotics. A study of 100 VAP patients reported that mortality rates were significantly associated with a change in antibiotic therapy. Published result associated with 12 studies included 3571 patients with VAP, confirmed no statistical difference in all‐cause mortality between monotherapy and combination therapy, clinical cure, length of stay in ICU or adverse events. Studies comparing tigecycline versus imipenem‐cilastatin for clinical cure in the clinically evaluable population showed statistically significant increase in clinical cure for imipenem‐cilastatin. There was no statistical difference in all‐cause mortality between carbapenem and non‐carbapenem therapies or adverse events, but carbapenems were associated with a statistically significant increase in the clinical cure. Treatment strategy in VAP should be considered based on pathogen reports. Vigilant attention to patient clinical status recommended to be advantageous for considering limited spectrum antibiotics.</p>Zahra Tolou-GhamariArezoo PourdadZahra Foroughi
Copyright (c) 2023 American Journal of Experimental and Clinical Research
2023-12-212023-12-21101474477Endocarditis caused by Mycobacterium tuberculosis
https://ajecr.org/index.php/ajecr/article/view/10537
<p><em>Mycobacterium tuberculosis</em> (TB) is a worldwide danger to human health, with the potential to spread to all parts of the body, including the heart. Tuberculous endocarditis (TBE) is a rare form of tuberculosis that is often associated with miliary TB and the replacement of an infected prosthetic or native valve. Despite advances in the diagnosis of tuberculosis, extrapulmonary tuberculosis remains a challenge due to its difficulty in diagnosis. In most cases, TBE is only detected post-mortem. In order to better manage TBE in the future, there is a need to accelerate and develop more accurate diagnostic methods. This review paper looks at the literature on TBE from 1970 to 2021. The diagnosis of TBE is complicated by the fact that the symptoms can vary greatly depending on the individual, and the disease can remain asymptomatic for long periods of time. The most common symptoms of TBE include fever, fatigue, joint pain, and an irregular heartbeat. Other symptoms can include chest pain, shortness of breath, and swelling of the extremities. Diagnosis is often made through a combination of physical examination, laboratory tests, and imaging. Treatment usually involves a combination of antibiotics and surgery. In some cases, valve replacement may be necessary. It is important to note that the prognosis of TBE is variable and depends on the individual's overall health, the stage of the disease, and the type of treatment received. Better management of TBE in the future requires acceleration and evolution of diagnostic methods. In this study, we review the literature on TBE from 1970 to 2021.</p>Maryam RafieeFatemeh Nemati ShahriOmid PouresmaeilReza AhmadiReyhaneh NoorizadehJalal Mardaneh
Copyright (c) 2023 American Journal of Experimental and Clinical Research
2023-12-212023-12-21101478484